Anemia is a common disease in both developed and developing ries. About 196 million people in the world have this disease, and hemolytic anemia is one of them. The causes of hemolysis are usually divided into acquired or acquired Common acquired causes of hereditary, hemolytic anemia are autoimmunity, microangiopathy, and infection. Hemolysis of the immune response caused by anti-erythrocyte antibodies may be caused by malignant tumors, autoimmune diseases, drugs and transfusion reactions; Danggui Buxue Decoction, from 1247 AD, Li Gao’s Theory of Differentiating Internal and External Injury, is composed of Danggui, Scutellaria baicalensis is mixed and boiled in a ratio of 1:5. Its composition is simple and the drug ratio is clear and uncontroversial. It is an index prescription of traditional Chinese medicine in the treatment of patients with blood deficiency syndrome. In addition, because of its special proportion, it reflects the traditional Chinese medicine. When thinking about qi and blood, Chinese medicine often says that "blood is the mother of qi, and qi is the leader of blood." , so in a prescription that mainly nourishes blood, traditional medicines that mainly nourish qi ac for a larger proportion. Research in the past ten years has pointed out that due to its simple composition, Danggui Buxue Decoction has been studied in many studies on anemia. In some anemia animal models, it can be found that it can promote the secretion of erythropoietin, reduce platelets and improve immunity.However, there are lacking in comprehensive studies of Danggui Buxue Decoction in animal models of hemolytic anemia induced by phenylhydrazine. Therefore, the goal of this study is to explore the protective effect of the water extract of Danggui Buxue Decoction on anemia and evaluate the impact on red blood cell (RBC) and hemoglobin. After 2 days of inducing hemolytic anemia, the experimental group was further divided into the calculated normal dose group, double dose group and standard treatment group using supportive therapy. After 5 days of feeding with the water extract of Danggui Buxue Decoction, It was concluded that both Hemoglobin and RBC in the double-dose group had a significant increasing effect compared with the control group. This study is a relatively extensive discussion of the therapeutic effect of hemolytic anemia. The current results can lay the foundation for future research on clinical anemia treatment. It is hoped that when more updated animal anemia models are established in the future, such as Autoimmune hemolytic anemia, etc., have more complete information on animal studies for reference, which can be extended to further clinical research.
【Keywords】
anemia； Danggui Buxue Tang； phenylhydrazine； animal model
281.1 當歸補血湯水萃物對PHZ誘導貧血大鼠的療效
