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Purpose：Alzheimer’s disease (AD) is characterized by neuropathological hallmarks such as senileplaque and neurofibrillary tangles caused by the amyloid β peptide (Aβ1-40). For this reason, we demonstratedthe role of the improve effect of Achyranthesbidentata against continuous intracisternal injection of Aβ1-40 in rats
Materials & Methods：This present result obtained total saponins and total polysaccharides extracted from Actyranthes bidentate (ABS and ABP) by 80% ethanol and distilled water. We further investigated the effects of ABS and ABP on the memory function caused by Aβ1-40 in rats. Intracisternal injection of Aβ1-40
caused the dysfunction of memory function on water maze.
Results：Pretreatment with ABS at a dosage of 50 mg/kg or ABP at 100 mg/kg reversed the dysfunction of memory function on water maze caused by intracisternal injection of Aβ1-40.
Conclusions：ABS and ABP can improve the learning and memory impairment of rat water maze induced by Aβ1-40, which can be used as a reference for clinical basic research of traditional Chinese medicine.
Keywords： amyloid β peptide, Alzheimer’s disease, water maze, Actyranthes bidentate
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212.1 牛膝改善大鼠學習記憶障礙之研究
