中醫藥研究論叢

211.5 人參與Warfarin 交互作用文獻回顧
TJ TCM.21(1) : 51-56, 2018
人參與Warfarin 交互作用文獻回顧
Literature Review of the Interaction between Ginseng and Warfarin
陳威傑1 莊筱梅1 陳昱瑋2 許航甄3 蔡嘉一1*
1 臺中榮民總醫院傳統醫學科,台中,台灣
2 臺中榮民總醫院嘉義分院心臟內科,嘉義,台灣
3 中山醫學大學附設醫院中西整合醫療科,台中,台灣
【摘要】
在現代醫學環境中,中藥與西藥彼此間交互作用逐漸受到重視。人參是中醫在臨床使用上很重要的藥物,常被應用在於體質屬於心肺脾虛的族群上,但卻被發現可能與抗凝血用藥產生交互作用。這樣交互作用下可能會產生危及生命的風險,因此人參與Warfarin 交互作用是值得進一步探討。回顧國內外文獻,發現以中草藥而言,人參是最被熱烈討論在與Warfarin 產生交互作用,然而在過去文獻研究上,人參與Warfarin 交互作用充滿衝突結果,深入分析與探討可以歸結出幾個重點給同道參考。對於使用Warfarin 的族群,人參劑量、服用人參週數以及體質因素是產生交互作用的重要關鍵。期許在未來上可以做出更貼近臨床事實的研究,以進一步釐清問題所在。
【關鍵詞】人參、Warfarin、藥物交互作用
Wei-Chieh Chen1 Hsiao-Mei Chuang1 Yu-Wei Chen2 Hang-Chen Hsu3 Chia-I Tsai1*
1Department of Chinese medicine,Taichung Veterans General Hospital, Taichung, Taiwan
2Division of Cardiology, Department of Internal Medicine, Taichung Veterans General Hospital
Chiayi Branch, Chiayi, Taiwan
3Department of Integrated Chinese and Western Medicine, Chung Shan Medical University
Hospital, Taichung, Taiwan
【Summary】
In modern medical environment, the awareness of the interaction between traditional Chinese medicine and western medicine has been gradually raise. Commonly used in clinical practice, Ginseng is an important Chinese herb, and is applied to patients with qi deficiency of heart, lung and spleen. However, it’s found to have an interaction with anticoagulant drugs, which may cause life-threatening risks. As a result, it is worth further exploring the interaction between use of Ginseng and Warfarin. Of the reviews of domestic and international literatures, Ginseng has been the most commonly cited Chinese herb in terms of the interaction with use of Warfarin. However, the effect of Ginseng on Warfarin has been reported with abundant conflicting results according to the past literature research. After our review and discussion, we can conclude several points for physicians as reference. The key factor of the interaction between Ginseng and Warfarin lies in the dose and time length of use of Ginseng and individual constitutional factors. To sum up, advanced clinical facts of research will be expected to further clarify the problem.
KeywordsGinseng, warfarin, drug interaction